D58: ICD10 Code for Other hereditary hemolytic anemias
D58 is the ICD10 code used for documenting Other hereditary hemolytic anemias in clinical and billing records.

D58 refers to Other hereditary hemolytic anemias, a group of anemias characterized by the destruction of red blood cells (hemolysis) either due to genetic mutations or external/acquired factors. These conditions often require lifelong management and are associated with varying degrees of severity.
Symptoms
- Fatigue – Due to decreased oxygen delivery
- Jaundice – From bilirubin buildup following red cell breakdown
- Dark urine – Indicative of hemoglobinuria
- Pallor – From anemia
- Enlarged spleen – Common in hemolytic conditions
- Delayed growth – Especially in pediatric hereditary cases
- Bone deformities – Seen in thalassemia due to marrow expansion
Diagnosis
Diagnosis of Other hereditary hemolytic anemias includes complete blood count, reticulocyte count, peripheral smear, bilirubin levels, haptoglobin, LDH, hemoglobin electrophoresis, and genetic or enzymatic assays. Family history and clinical presentation also help differentiate between hereditary and acquired types.
ICD10 Code Usage
ICD10 code D58 is used in hematology and general practice to classify hemolytic anemias for diagnosis, treatment planning, insurance billing, and genetic counseling. It’s critical for monitoring disease progression and treatment efficacy.
Related Codes
- D55 – Anemia due to enzyme disorders
- D56 – Thalassemia
- D57 – Sickle-cell disorders
- D59 – Acquired hemolytic anemia
FAQs
Q1: What is ICD10 code D58?
A: It refers to Other hereditary hemolytic anemias, covering various hemolytic anemias, either inherited or acquired.
Q2: What causes these anemias?
A: Genetic mutations (e.g., G6PD deficiency, sickle cell, thalassemia) or acquired triggers like autoimmune disorders or certain drugs.
Q3: Are these lifelong conditions?
A: Most hereditary types are lifelong. Acquired forms may be temporary or chronic depending on the cause.
Q4: How are they managed?
A: Supportive care, transfusions, iron chelation, immunosuppressants, splenectomy, or bone marrow transplant in severe cases.
Q5: Who is at risk?
A: Individuals with family history or certain ethnic backgrounds (e.g., Mediterranean, African, Southeast Asian) are at higher risk for hereditary forms.
Conclusion
ICD10 code D58 plays an essential role in diagnosing and managing Other hereditary hemolytic anemias. It ensures appropriate medical documentation, helps track disease outcomes, and supports access to necessary treatments and follow-up care in patients with hemolytic anemia.

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